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A flash flood watch is in effect for San Antonio and much of the Hill Country from 7 p.m. Friday night until 1 p.m. Saturday.
A Pacific cold front is pushing through South Texas to trigger rain showers.
The National Weather Service reports widespread amounts of 1 to 3 inches of rain are possible with isolated amounts up to 5 inches for some areas.
The federal weather agency said excessive runoff may result in life-threatening flooding of rivers, creeks, streams, and other low-lying locations.
Gusty winds, hail, and an isolated tornado cannot be completely ruled out.
Much of South-Central Texas needs relief in the midst of a six-year drought that has seen waterways and waterflows dwindle.
San Antonio residents remain under Stage 3 water restrictions and may only water once a week with automated sprinklers based on their street address.
Hand-watering with a garden hose is still permitted at any time, according to the San Antonio Water System.