ketamine

In zebrafish, ketamine causes changes a brain circuit involved in "giving up." That may help explain how the drug helps people with depression.

In a recent small study, the antidepressant effects of ketamine lasted longer when an intravenous dose was followed with computer games featuring smiling faces or words aimed at boosting self-esteem.

A medicine best known as a club drug has a record of relieving suicidal depression in hours. National Institutes of Health researcher Dr. Carlos Zarate…